Dermatitis Research Today is a free monthly online journal that collates and summarizes the latest research about Dermatitis, including details on contact-, seborrheic-, atopic-, allergic-dermatitis, treatment.

T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.

Li S, Zhu F, Zykova T, Kim MO, Cho YY, Bode AM, Peng C, Ma W, Carper A, Langfald A, Dong Z

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.

Solar UV radiation is a major environmental factor that causes DNA damage, inflammation, and even skin cancer. T-LAK cell-originated protein kinase (TOPK) is expressed widely in both normal and cancer cells and functions to inhibit apoptosis and promote carcinogenesis. However, its function in inflammation is not known. The p38 MAPK signaling pathway plays an important role in solar UV light-induced inflammation. In this study, we found that TOPK negatively regulated the activity of p38α by phosphorylating the p38α-specific phosphatase MKP1 and enhancing the stability of MKP1. Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation.

Published 22 August 2011 in J Biol Chem, 286(34): 29601-9.
Full-text of this article is available online (may require subscription).

Articles on Dermatitis published 16 August 2011:

Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation.   J Invest Dermatol, 131(9): 1838-44.

JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the pathogenesis of inflammatory skin diseases such as psoriasis and atopic dermatitis (AD). Direct antagonism of cytokines, such as IL-12 and IL-23 using ustekinumab, has proven effective in randomized studies in psoriasis patients. We hypothesized that local inhibition of cytokine signaling using topical administration of INCB018424, a small ... [Abstract] [Full-text]

Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.   J Invest Dermatol, 131(9): 1845-52.

Although topical glucocorticoids (GCs) show potent anti-inflammatory activity in inflamed skin, they can also exert numerous harmful effects on epidermal structure and function. In contrast, topical applications of ligands of peroxisome proliferator-activated receptor-α (PPARα) not only reduce inflammation but also improve cutaneous barrier homeostasis. Therefore, we examined whether sequential topical GCs followed by topical Wy14643 (a ligand of PPARα) might be more effective than either ... [Abstract] [Full-text]

Blocking MAPK signaling downregulates CCL21 in lymphatic endothelial cells and impairs contact hypersensitivity responses.   J Invest Dermatol, 131(9): 1927-35.

CCL21 expression by lymphatic endothelial cells (LECs) is essential for migration of CCR7+ immune cells from skin to regional lymph nodes (LNs). We investigated the importance of mitogen-activated protein kinase (MAPK) signaling in CCL21 expression by ECs in vitro and in vivo. Normal human dermal lymphatic microvascular ECs (HMVEC-dLy) stimulated in vitro with oncostatin M (OSM) expressed high amounts of CCL21 mRNA. CCL21 protein expression by HMVEC-dLy was also markedly increased by OSM ... [Abstract] [Full-text]

Articles on Dermatitis published 15 August 2011:

Topical nitroglycerin: a promising treatment option for chondrodermatitis nodularis helicis.   J Am Acad Dermatol, 65(3): 531-6.

[Abstract] [Full-text]

Articles on Dermatitis published 9 August 2011:

Contact dermatitis caused by dimethylfumarate in Argentina.   Clin Toxicol (Phila), 49(6): 508-9.

For the first time in Argentina, we describe an outbreak of contact dermatitis. New pairs of shoes caused intense pruritus, pain, and eruption, followed by edema, blisters, and a severe negative impact on the epidermal barrier of the feet. We identify dimethylfumarate as the causal agent and suggest an analytical method for its fast identification. [Abstract] [Full-text]

Articles on Dermatitis published 8 August 2011:

Erlotinib-induced rash spares previously irradiated skin.   Strahlenther Onkol, 187(8): 499-501.

[Abstract] [Full-text]

Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients.   Strahlenther Onkol, 187(8): 485-91.

[Abstract] [Full-text]

Articles on Dermatitis published 5 August 2011:

Grade 3/4 dermatitis in head and neck cancer patients treated with concurrent cetuximab and IMRT.   Int J Radiat Oncol Biol Phys, 81(1): 110-7.

[Abstract] [Full-text]

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