Dermatitis Research Today is a free monthly online journal that collates and summarizes the latest research about Dermatitis, including details on contact-, seborrheic-, atopic-, allergic-dermatitis, treatment.

Topical streptococcal preparation, OK-432, for atopic dermatitis.

Horiuchi Y

Division of Dermatology, Tsukuba Memorial Hospital, Tsukuba City, Ibaraki, Japan. nu-yhori@jcom.home.ne.jp

Effective treatment of atopic dermatitis (AD) may in some cases prove quite difficult. OK-432, prepared from the penicillin-treated Su strain of type III Group A Streptococcus pyogenes, has been shown to be effective for treating not only cancer but verruca vulgaris as well, suggesting this agent to create the Th1 pathway through IL-12 induction. Four AD patients consented to trial use of the OK-432 ointment. OK-432 was found to bring about complete cure in the present four cases. Based on results from its use, OK-432 may be concluded to be highly effective for treating AD.

Published 15 July 2005 in J Dermatolog Treat, 16(2): 117-20.
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