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Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency.

Torrelo A, Vera A, Portugués M, de Prada I, Sanz A, Colmenero I, Zulaica A, de Lucas R, Fraga J, Pedraz J, Fontán S, Zambrano A

Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain. atorrelo@aedv.es

We report two newborns with a widespread cutaneous eruption consisting of discrete papules which evolved into vesicles, pustules, crusts, and ulcers. These healed over a 2-week period with scarring. Histopathology showed three main features--histiocytic granulomas, neutrophilic infiltration, and transepidermal elimination of degenerated collagen and debris through hair follicles. Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described.

Published 4 June 2007 in Pediatr Dermatol, 24(3): 211-5.
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